This event originally took place on June 13; the date was mistakenly updated to a later time during edits made the day before.

Limited availability. Please register! https://gladstone.org/form/gind-ppg-symposium-2025

Join us for a one-day symposium to explore cutting-edge approaches to understanding and combating Alzheimer’s disease. This event will spotlight innovative strategies to model, decode, and disrupt the multifactorial etiology of this challenging condition.

What to Expect

• Presentations from leading researchers in the field
• Insights into emerging scientific directions and technologies
• Interactive Q&A discussions bridging diverse areas of Alzheimer’s research
• A lunchtime poster session featuring new ideas and ongoing work from fellow researchers

Introduction and Overview

9:00 – 9:15am Lennart Mucke, MD
Director, Gladstone Institute of Neurological Disease
Professor of Neurology and Neuroscience, University of California San Francisco

Presentations

9:20 – 9:55am | Dynamic dysregulation of parvalbumin cell states underlies altered gamma oscillations and brain hyperexcitability in Alzheimer’s disease
Jorge Palop, PhD
Associate Investigator, Gladstone Institute of Neurological Disease
Associate Professor of Neurology, University of California San Francisco

10:00 – 10:35am | Multi-regional disease trajectories and selective cellular vulnerabilities in Alzheimer's Disease
Ed Lein, PhD
Senior Investigator, Allen Institute for Brain Science
Affiliate Professor, Departments of Neurological Surgery and Laboratory Medicine and Pathology (DLMP), University of Washington

10:35 – 10:45am Break

10:45 – 11:20am | Study of APOE2′s Protective Role in Alzheimer’s Disease
Yadong Huang, MD, PhD
Senior Investigator, Gladstone Institute of Neurological Disease
Professor of Neurology and Pathology, University of California San Francisco

11:25am – 12:00pm | Microglia-Based Cell Therapies for the Brain
Marius Wernig, MD, PhD
Professor, Departments of Pathology and Chemical and Systems Biology,
Co-Director, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
Visiting Scientist, Gladstone Institute of Cardiovascular Disease

12:00 – 1:30pm Lunch and Poster Session

1:35 – 2:10pm | Leveraging Single-Cell Biology to Understand the Noncoding Genome in Alzheimer’s Disease
Ryan Corces, PhD
Assistant Investigator, Gladstone Institute of Neurological Disease
Assistant Professor of Neurology, University of California San Francisco

2:15 – 2:50pm | Dissecting Molecular Heterogeneity in Alzheimer’s Disease at the Cell-Type Level
Vilas Menon, PhD
Assistant Professor, Department of Neurology, Columbia University Irving Medical Center

2:55 – 3:30pm | Statistical Models to Assess Changes in Cell-Type Composition in Single Cell Studies
Reuben Thomas, PhD
Associate Director, Bioinformatics Core, Gladstone Institute of Data Science and Biotechnology

3:30 – 3:45pm Break

3:45 – 4:20pm | Using Complex Genetics in Mice to Unlock the Secrets of Cognitive Resilience
Catherine Kaczorowski, PhD
Elinor Levine Professor of Dementia Research and Professor of Neurology, Deputy Director of Intervention Testing Program, University of Michigan

4:25 – 5:00pm | Tau Lowering Therapeutic Strategies to Prevent and Reverse Alzheimer’s Disease Related Brain Dysfunctions
Lennart Mucke, MD
Director, Gladstone Institute of Neurological Disease
Professor of Neurology and Neuroscience, University of California San Francisco

5:00 – 5:10pm | Closing Remarks by Yadong Huang, MD, PhD
Senior Investigator, Gladstone Institute of Neurological Disease
Professor of Neurology and Pathology, University of California San Francisco

Limited availability. Please register! https://gladstone.org/form/gind-ppg-symposium-2025

This event is supported by NIA Research Program Project Grant P01 AG073082.

Hosted by the Gladstone Institute of Neurological Disease.

For more details, contact Randi Mott (randi.mott@gladstone.ucsf.edu)