QBI presents the inaugural QBI Bay Area Symposium on Chemical Biology on September 26-27, 2022, organized by Drs. Jim Wells, Kevan Shokat, Jason Gestwicki, Chris Chang, and Carolyn Bertozzi. Under the leadership of Dr. Nevan Krogan, the Quantitative Biosciences Institute (QBI) seeks transformative results in biomedicine by supporting fundamental quantitative research in the biological sciences.

In support of this mission, the meeting will focus on the latest cutting edge Chemical Biology research to address unmet biological problems with new technologies and targets from top scientists in the Bay Area.

The meeting will provide opportunities for scientists at all career stages, including faculty, undergrad, graduate and postdoc levels to present their research in dynamic talks, Twitter interviews, panel discussions, poster sessions and mixers.

Confirmed Speakers:

Matt Bogyo, Stanford University

Paul Carter, Genentech

Jamie Cate, University of California, Berkeley

Chris Chang, University of California, Berkeley

Michelle Chang, University of California, Berkeley

James Chen, Stanford University

Charly Craik, University of California, San Francisco

Laura Dassama, Stanford University

Bill DeGrado, University of California, Berkeley

Jennifer Doudna, University of California, Berkeley

Pam England, University of California, San Francisco

Polly Fordyce, Stanford University

Matt Francis, University of California, Berkeley

Danica Fujimori, University of California, San Francisco

Zev Gartner, University of California, San Francisco

Jason Gestwicki, University of California, San Francisco

Nathanael Gray, Stanford University

Natalia Jura, University of California, San Francisco

Peter Kim, Stanford University

Eric Kool, Stanford University

Misty Kuhn, San Francisco State University

Lingyin Li, Stanford University

John Link, Gilead Sciences

Michael Marletta, University of California, Berkeley

Nicole Martinez, Stanford University

Evan Miller, University of California, Berkeley

Dan Nomura, University of California, Berkeley

Adam Renslo, University of California, San Francisco

Alanna Schepartz, University of California, Berkeley

Ian Seiple, University of California, San Francisco

Jason Sello, University of California, San Francisco

Kevan Shokat, University of California, San Francisco

Xiaokun Shu, University of California, San Francisco

Jack Taunton, University of California, San Francisco

Alice Ting, Stanford University

Lei Wang, University of California, San Francisco

Jim Wells, University of California, San Francisco

Allison Williams, University of California, San Francisco

Balyn Zaro, University of California, San Francisco

Wenjun Zhang, University of California, Berkeley

AGENDA

Day 1 - September 26th

8:00 AM: Registration & Breakfast

9:00-9:10 AM: Symposium begins: Welcome from organizers 

Session 1 - 9:10-10:25 AM: Chemical Biology of Metals | Chaired by: Nathanael Gray

9:10 AM Chris Chang | Transition Metal Signaling and Metalloallostery: Bioinorganic Chemistry Beyond Active Site

9:20 AM  Michelle Chang | Synthetic biology approaches to new chemistry

9:30 AM  Adam Renslo | Chemical tools to study labile iron in cells and animals

9:40 AM  Laura Dassama | Chemical biology tools for hematologic disorders

9:50 AM  Michael Marletta | Probing for novel therapeutic targets in human and plant disease

10:00 AM  Jim Wells | Proximity labeling for high resolution protein neighborhoods

10:10 AM  15 min questions

10:25-10:45 AM: Break Coffee Tea Cookies

Session 2 - 10:45-12:00 PM: Chemoproteomics and Covalent Therapeutics | Chaired by: Danica Fujimori

10:45 AM  Dan Nomura | Reimagining Druggability using Chemoproteomic Platforms

10:55 AM  Nathanael Gray | Extending the Reach of Kinase Inhibitor therapy using new targeting Strategies

11:05 AM  Jack Taunton | Trapped on the ribosome

11:15 AM  Lei Wang | New covalent bonding ability for proteins

11:25 AM  Charles Craik | Targeting an intracellular oncogene with immunotherapy against a haptenanted neoepitope

11:35 AM  Kevan Shokat | Expansion of Covalent Chemistry to Target the Undruggable Oncogenic Mutants of K-RAS

11:45 AM  15 min questions

12:00-1:15 PM: Lunch 

Session 3 - 1:15-2:20 PM: Engineered Sensors for Proteins, Cells and Animals | Chaired by: Michael Marletta

1:15 PM  Alanna Schepartz | Protein delivery

1:25 PM  Evan Miller | Fiat Lux: Fluorescent indicators to watch cellular physiology

1:35 PM  Xiaokun Shu | Functions of protein phase separation in chromatin structure and transcription

1:45 PM  Polly Fordyce | Microfluidics for high-throughput biochemistry and biophysics

1:55 PM  Matt Bogyo | Mapping proteases in the gut microbiome with small molecule probes

2:05 PM  15 min questions

2:20-2:45 PM: Coffee Break

Session 4 - 2:45-4:00 PM: Protein and Tissue Engineering | Chaired by: Alanna Schepartz

2:45 PM  Paul Carter | Probing the Molecular Basis of High Viscosity of Monospecific and Bispecific IgG Antibodies (tentative title)

2:55 PM  Matt Francis | Synthesis of Protein-Protein Conjugates Using Enzymatic Oxidative Coupling Reactions

3:05 PM  Zev Gartner | What is tissue structure good for?

3:15 PM  Bill Degrado | De Novo Protein Design

3:25 PM  Alice Ting | TBD

3:35 PM  Peter Kim | Broad-spectrum protection and treatment of SARS-CoV-2

3:45 PM  15 min questions

4:00-4:45 PM: Industry Leaders (New Visions and Challenges for Pharma)

  Moderator: Jim Wells; Panelists: Andrew Chan, Ray Deshaies, Shiva Malek

4:45-5:00 PM: Closing remarks

5:00-6:00 PM: Poster Session

6:00-7:00 PM: Reception

Day 2 - September 27th

8:00 AM: Registration & Breakfast

9:00-9:10 AM: Symposium begins: Welcome speech by organizers 

Session 5 - 9:10-10:25 AM: Natural and Synthetic Small Molecules in Drug Discovery and Therapy | Chaired by: Peter Kim

9:10 AM  James Chen | Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1

9:20 AM  Jason Sello | Illuminating Biology with Bioactive Small Molecules

9:30 AM  Wenjun Zhang | Bioactive natural product discovery and biosynthesis

9:40 AM  Ian Seiple | Chemical synthesis to unlock natural product potential

9:50 AM  Pam England | Developing Nurr1 Modulators for Treating Neurodegneration

10:00 AM John Link | Lenacapavir: A Twice-Yearly Dosed First-in-Class HIV Capsid Inhibitor

10:10 AM  15 min questions

10:25-10:40 AM: Break 

Session 6 - 10:40-11:45 AM: Chemical Microbiology and Immunology | Chaired by: Bill DeGrado

10:40 AM  Jaime Cate | Translating T cell biology

10:50 AM  Balyn Zaro | Bacterial Mimicry of Mammalian 'Don't Eat Me' Signals

11:00 AM  Allison Williams | Decoding bacterial host communication

11:10 AM  Misty Kuhn | Unraveling polyamine acetyltransferase allosteric networks

11:20 AM  Lingyin Li | Chemical biology of the innate immune STING pathway

11:30 AM  15 min questions

11:45-1:30 PM: Lunch

1:30-1:45 PM: Twitter Interview: Gene Editing 

  Host: Jason Gestwicki; Guest: Jennifer Doudna

Session 7 - 1:45-2:50 PM: Intracellular Signaling | Chaired by: Chris Chang

1:45 PM  Eric Kool | RNA acylation as a universal tool for transcriptome studies

1:55 PM  Nicole Martinez | Uncovering new functions of the RNA modifications in mRNA processing

2:05 PM  Danica Fujimori | Proximity Reactive Cyclic Peptides as Covalent Probes for Epigenetic Proteins

2:15 PM  Natalia Jura | Mechanistic insights into signaling by protein kinases

2:25 PM  Jason Gestwicki | Protein-Protein Interactions at C-Termini Regulate Protein Stability

2:35 PM  15 min questions

2:50-4:00 PM: Poster Session with refreshments

4:00-4:45 PM: Entrepreneur Panel (Translating Commercial Reality)

  Moderator: Kevan Shokat; Panelists: Charles Homcy, Patrick Baeuerle

4:45-5:00 PM: Closing remarks/(Top 3 Posters Announced)

5:00-7:00 PM: Final Reception and Celebration