Gladstone Institutes and QBI present the Infectious Diseases and Human Health Mini-Symposium Series, featuring the edition: "HIV Persistence: Where We Are Now and Where We Need to Go."

Antiretroviral therapy (ART) has revolutionized the treatment of people with HIV and of viral infections in general. However, it does not represent a cure as a reservoir of replication-competent proviruses remains and rebounds after ART is stopped. This symposium explores basic mechanisms of viral persistence, characteristics of the reservoir and its transcriptional activity, as well as novel methods of suppressing viral rebound and promoting a (functional) cure.

AGENDA

1:00-1:10 | Welcome & Opening Remarks

1:10 - 1:35 | Nicolas Chomont - HIV reservoirs: Where does HIV hide?

1:35 - 2:00 | Nancie Archin - How much is enough? Combination latency reversal to allow clearance

2:00 - 2:25 | Stephane Emiliani - Transcriptional Control via Termination complexes: Insights from HIV and host Genes

2:25 - 2:50 | Melanie Ott - Silencing the transcriptionally active HIV reservoir 

2:50 - 3:30 Networking Break

3:30 - 3:55 | Nevan Krogan - Understanding the mechanisms of HIV infection using systems approaches

3:55 - 4:20 | Morgane Rolland - Correlates of Time to Viral Rebound Across RV254 ATI Studies

4:20 - 4:45 | Linos Vandekerckhove - Challenges to link rebounding virus to the viral reservoir in PLWH

4:45 - 4:55 Closing Remarks