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X-WR-CALNAME:Mitochondrial long-lived proteins - what are they and why do t
 hey exist? 
X-WR-TIMEZONE:Pacific Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20261005T181641Z
UID:tag:localist.com\,2008:EventInstance_49022943118371
DTSTART:20250305T190000Z
DTEND:20250305T200000Z
DESCRIPTION:QBI presents a seminar with Ewa Bomba-Warczak\, a tenure track 
 Assistant Professor in the Department of Physiology at the University of P
 ennsylvania Perelman School of Medicine.\n\nDr. Bomba-Warczak's research i
 nvestigates how cells with exceptionally long lifespans – neurons and oo
 cytes - establish and maintain their mitochondrial networks throughout the
 ir life\, and how the stability of mitochondrial components contributes to
  cell’s health and age-dependent degeneration. In her laboratory she com
 bines in vitro cell and in vivo mouse models with mass spectrometry-based 
 proteomics\, biochemistry\, genetics\, and fluorescent imaging to define t
 he mechanisms governing the lifelong mitochondrial homeostasis in health a
 nd disease. \n\nDr. Bomba-Warczak received her PhD in Neuroscience from th
 e University of Wisconsin – Madison in 2017 in the laboratory of Dr. Edw
 in Chapman\, and HHMI Investigator\, followed by postdoctoral studies unde
 r the mentorship of Dr. Jeffrey Savas at Northwestern University. She rece
 ived her B.S. in Biological Sciences with honors from University of Illino
 is at Chicago. She is a recipient of a Jerzy Rose Award for most outstandi
 ng graduate thesis in Neuroscience at the University of Wisconsin-Madison\
 , NIH F32 Fellowship and NIH MOSAIC K99 Pathway to Independence Fellowship
  to Promote Diversity. She has been named a Leading Edge Fellow (class of 
 2023) and recently a Keystone Fellow (class of 2025). She is also a co-fou
 nder of MITOchats\, an online seminar series featuring graduate students a
 nd postdoctoral fellows working in the field of mitochondria. \n\nTalk Tit
 le: Mitochondrial Long-lived Proteins - What Are They and Why Do They Exis
 t? \n\nContinuous replenishment of mitochondria is essential for maintaini
 ng high-quality organelles throughout the lifespan of post-mitotic and lon
 g-lived cells. Age-related impairments in mitochondrial renewal contribute
  to progressive cellular and tissue degeneration. Accordingly\, the averag
 e half-life of mitochondrial proteins in the mammalian brain is estimated 
 at less than 3 weeks. However\, we found that a discrete subset of the mit
 ochondrial proteome persists for months in mammalian brains\, hearts\, and
  oocytes\, without being turned over. These mitochondrial long-lived prote
 ins\, or mt-LLPs\, are enriched at cristae invaginations and include OxPho
 s\, MICOS\, mt-DNA proteins\, chaperones\, and cytochrome C.\n\nDr. Bomba-
 Warczak's group performed cross-linking MS-based quantitative analysis on 
 native OxPhos complexes which revealed a significant spatial restriction o
 f mt-LLPS and co-preservation within same cristae. Since cristae stability
  is intimately coupled to mitochondrial function\, they propose that mt-LL
 Ps could play a previously unrecognized role in the long-term stabilizatio
 n of mitochondrial ultrastructure\, which in turn might be imperative for 
 mitochondrial fitness. Their ongoing research efforts are centered on (1) 
 the investigation of molecular quality-control mechanisms governing the ex
 ceptional persistence of mt-LLPs\, (2) the spatio-temporal distribution of
  mt-LLP within mitochondrial networks in two types of long-lived cells: ne
 urons and oocytes\, and (3) their persistence in the context of cristae st
 ability and remodeling. Insights from this work will provide with a new un
 derstanding of the role of long-lived proteins in post-mitotic and long-li
 ved cells and could lead to novel targets for potential therapeutic interv
 entions for both neurological disorders and reproductive health. \n\nHoste
 d by Nevan Krogan
GEO:37.76755;-122.39038
LOCATION:Mission Hall\, 1406
SUMMARY:Mitochondrial long-lived proteins - what are they and why do they e
 xist? 
URL;VALUE=URI:https://calendar.ucsf.edu/event/mitochondrial-long-lived-prot
 eins-what-are-they-and-why-do-they-exist
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