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CADASIL: from NOTCH3 and beyond

Michael Wang, MD, PhD
Professor, Neurology
Professor, Molecular and Integrative Physiology
Director, VA Hospital, Neurology
University of Michigan


  • To review the clinical characteristics of CADASIL
  • To discuss the current understanding of the molecular basis of CADASIL
  • To describe evolving insights into how NOTCH3 mutations alter protein conformation


  • Planners: Bruce L. Miller, MD; Howard J. Rosen, MD; Andrew Breithaupt, MD; and Eleanor O’Brien have stated they have no relationships to disclose.
  • Speakers: Michael Wang, MD, PhD, has stated he has no relationships to disclose.

Accreditation: The University of California, San Francisco (UCSF) School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Designation: UCSF designates this live activity for a maximum of 22 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Credit is inclusive of all Memory and Aging Center Grand Rounds sessions offered from January 1, 2022, through December 30, 2022. (1 credit per each 1-hour grand rounds session throughout the year).

Questions? Email Andrew Breithaupt, MD, at

Attendees must register for this event. Grand Rounds presentations are for educational purposes and intended for a professional audience with a terminal degree. This activity is not commercially supported.

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