Name: Memory and Aging Center Journal Club
Start: 2025-03-24T10:00:00-07:00
End: 2025-03-24T11:00:00-07:00
Location: Sandler Neurosciences Center

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Sandler Neurosciences Center, Neuroscience Conference Center (NSCC) View map

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675 Nelson Rising Lane, San Francisco, CA

https://memory.ucsf.edu #UCSFmac

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Dr. Brandon Holmes and Brandon Apresa will present a new paper in Neuron on the ApoE3 R136S "Christchurch" mutation (first identified by Yakeel Quiroz, Francisco Lopera, and their team in Colombia) examining the mechanisms in mouse models. Audience discussion afterward.

Chen G, Wang M, Zhang Z, Hong DK, Ahn EH, Liu X, Kang SS, Ye K. ApoE3 R136S binds to Tau and blocks its propagation, suppressing neurodegeneration in mice with Alzheimer's disease. Neuron. 2025:S0896-6273(24)00914-0. doi: 10.1016/j.neuron.2024.12.015.

Journal club presentations are for educational purposes and intended for a professional audience with a terminal degree. This activity is not commercially supported.

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UCSF promotes the exchange of diverse ideas and perspectives, acknowledging that the views and opinions of our guest speakers on campus are their own and may not reflect the perspective of the University. We embrace free speech in the pursuit of greater understanding, consistent with our obligations as a public university under the First Amendment.