Integrative Single-Cell Genomic Approaches to Dissect Alzheimer's Disease Mechanisms

Li-Huei Tsai, PhD
Director, The Picower Institute for Learning and Memory at MIT
‌Picower Professor of Neuroscience, Department of Brain and Cognitive Sciences
‌Senior Associate Member, Broad Institute

Learning Objectives

• Using single-cell transcriptomic and epigenomic approaches to study postmortem human brain samples.
• Learning Alzheimer’s disease risk genes involved in cholesterol and lipid metabolism.
• Using human induced pluripotent stem cells to model Alzheimer’s disease.

Disclosures

• Planners: Bruce L. Miller, MD; Howard J. Rosen, MD; Anil Vora; and Laura Wise have stated they have no relationships to disclose.
• Speaker: Li-Huei Tsai, PhD, has disclosed the following relationships: TAC Therapeutics, co-scientific founder and SAB member.

Accreditation: The University of California, San Francisco (UCSF) School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Designation: UCSF designates this live activity for a maximum of 22 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Credit is inclusive of all Memory and Aging Center Grand Rounds sessions offered from January 1, 2025, through December 31, 2025. (1 credit per each 1-hour grand rounds session throughout the year).

Virtual attendees must register for this event. Grand Rounds presentations are for educational purposes and intended for a professional audience with a terminal degree. This activity is not commercially supported.