Lost Connections: Modeling Synaptic Failure in FTD/ALS

Rita Sattler, PhD
Professor, Department of Translational Neuroscience
‌David and Weezie Reese Chair for Neurodegeneration Research
Barrow Neurological Institute

Learning Objectives

• Importance of synaptic dysfunction in neurodegenerative diseases.
• Utilization of patient-derived induced pluripotent stem cell (iPSC) culture models and postmortem brain tissue for studying neurodegenerative diseases.

Disclosures

• Planners: Bruce L. Miller, MD, Howard J. Rosen, MD, and Anil Vora have stated that they have no relationships with ineligible companies to disclose.
• Speaker: Rita Sattler, PhD, has disclosed the following relationships: Received consulting fees from Corsalex Inc. and Korro Bio Inc. Both relationships have ended.

Accreditation: In support of improving patient care, this activity has been planned and implemented by UCSF Office of CME and the Edward and Pearl Fein Memory and Aging Center. UCSF Office of CME is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team. 
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‌This CME activity meets the requirements under California Assembly Bill 1195 for continuing education and cultural and linguistic competency.

Designation: UCSF designates this live activity for a maximum of 22 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Credit is inclusive of all Edward and Pearl Fein Memory and Aging Center Grand Rounds sessions offered from January 1, 2026, through December 31, 2026. (1 credit per each 1-hour grand rounds session throughout the year).

Attendees must register for this event. Grand Rounds presentations are for educational purposes and intended for a professional audience with a terminal degree. This activity is not commercially supported.