Single-Neuron Genomes: ‌Lenses into the Pathogenesis of Neurodegeneration

Michael B. Miller, MD, PhD
Assistant Professor of Pathology, Harvard Medical School
‌Associate Pathologist, PI, Brigham and Women's Hospital

Learning Objectives

• Understand the relationship between somatic mutation accumulation and age in neurons.
• Recognize the features of neuronal somatic mutation accrual in neurodegeneration.
• Recognize somatic genomic similarities between CTE and Alzheimer's disease.

Disclosures

• Planners: Bruce L. Miller, MD; Howard J. Rosen, MD; Anil Vora; and Laura Wise have stated they have no relationships to disclose.
• Speaker: Michael B. Miller, MD, PhD, has stated he has no relationships to disclose.

Accreditation: The University of California, San Francisco (UCSF) School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Designation: UCSF designates this live activity for a maximum of 22 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Credit is inclusive of all Edward and Pearl Fein Memory and Aging Center Grand Rounds sessions offered from January 1, 2025, through December 31, 2025. (1 credit per each 1-hour grand rounds session throughout the year).

Virtual attendees must register for this event. Grand Rounds presentations are for educational purposes and intended for a professional audience with a terminal degree. This activity is not commercially supported.