From Traumatic Brain Injury ‌to Neurodegeneration: Mechanisms Linking Acute Injury to Chronic Neurodegeneration

Declan McGuone, FRCPath, MBBCh
Associate Professor of Pathology
Yale School of Medicine

Learning Objectives

• Explain how acute calcium dysregulation initiates early axonal and neuronal pathology.
• Describe post-traumatic TDP-43 and SARM1 pathways and their role in axonal degeneration.
• Summarize how acute injury mechanisms can progress to chronic neurodegeneration.

Disclosures

• Planners: Bruce L. Miller, MD; Howard J. Rosen, MD; Anil Vora; and Laura Wise have stated they have no relationships to disclose.
• Speaker: Declan McGuone, FRCPath, MBBCh, has stated he has no relationships to disclose.

Accreditation: The University of California, San Francisco (UCSF) School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Designation: UCSF designates this live activity for a maximum of 22 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Credit is inclusive of all Edward and Pearl Fein Memory and Aging Center Grand Rounds sessions offered from January 1, 2025, through December 31, 2025. (1 credit per each 1-hour grand rounds session throughout the year).

Virtual attendees must register for this event. Grand Rounds presentations are for educational purposes and intended for a professional audience with a terminal degree. This activity is not commercially supported.