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X-WR-CALNAME:David Fidock -Leveraging geneRc approaches to tackle the globa
 l spread of drug-resistant malaria
X-WR-TIMEZONE:Pacific Time (US & Canada)
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DTSTAMP:20260610T212443Z
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DTSTART:20220607T170000Z
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DESCRIPTION:https://imicro.ucsf.edu/seminar-series\n\nDuring my past 20 yea
 rs of malaria research\, I have investigated how P. falciparum invades and
  develops within hepatocytes and RBC\, what immune effector mechanisms ope
 rate on these stages\, how antimalarials act and how parasites counter the
 ir action\, and how parasites are successfully transmitted to Anopheles mo
 squitoes\, their definitive host. My laboratory's ongoing and planned rese
 arch channels these interests into several themes:\n\n1) What are the para
 site factors that mediate resistance to antimalarial drugs\;\n2) What biol
 ogical processes are targeted by antimalarial drugs and what accounts for 
 parasite death\;\n3) What biochemical and physiological functions are intr
 insic to the digestive vacuole (DV) and the apicoplast\, the site of actio
 n of CQ and of antibiotics respectively\; and \n4) How does P. falciparum 
 regulate its virulence and prevent the establishment of protective immunit
 y.\n\nThese studies benefit from our extensive experience in P. falciparum
  transfection and we constantly strive for new innovations in genetics to 
 enhance the power of these investigations.\n\nDavid A. Fidock\, Ph.D. Colo
 mbia University\n\nC.S. Hamish Young Professor of Microbiology & Immunolog
 y and Medical Sciences (in Medicine)\nPh.D.\, Pasteur Institute Paris
LOCATION:
SUMMARY:David Fidock -Leveraging geneRc approaches to tackle the global spr
 ead of drug-resistant malaria
URL;VALUE=URI:https://calendar.ucsf.edu/event/david_fidock_-leveraging_gene
 rc_approaches_to_tackle_the_global_spread_of_drug-resistant_malaria
CATEGORIES:Research & Academia
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