BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
X-WR-CALNAME:Cotranslational Assembly Defects Trigger a Proteostatic Killsw
 itch in the Ribosome
X-WR-TIMEZONE:Pacific Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260819T211138Z
UID:tag:localist.com\,2008:EventInstance_49366445493392
DTSTART:20250423T190000Z
DTEND:20250423T200000Z
DESCRIPTION:QBI presents a seminar with Jonathan Patrick Schlebach\, Associ
 ate Professor in the Department of Chemistry at Purdue University. Researc
 h in the Schlebach lab is focused on the biochemical and biophysical aspec
 ts of integral membrane protein biosynthesis\, folding\, and misfolding in
  the cell. Dr. Schlebach's laboratory utilizes an interdisciplinary array 
 of biochemical\, cellular\, and computational techniques in order to gain 
 mechanistic insights into the key reactions that modulate cellular protein
  homeostasis and to determine how they factor into the molecular mechanism
 s of evolution and disease. They are also adapting these tools and perspec
 tives to develop and target new precision therapeutics for various genetic
  diseases including cystic fibrosis\, retinitis pigmentosa\, and cerebral 
 creatine deficiency syndrome.\n\nTalk Title: Cotranslational Assembly Defe
 cts Trigger a Proteostatic Killswitch in the Ribosome\n\nThough the riboso
 me possesses several features that help maintain its translational reading
  frame\, certain transcripts contain RNA structures that override these me
 chanisms to promote ribosomal frameshifting. Dr. Schlebach's group recentl
 y found that conformational transitions in the nascent polypeptide can als
 o enhance the activity of a viral RNA structure that stimulates -1 program
 med ribosomal frameshifting (-1PRF). However\, it remains unclear whether 
 the nascent chain plays a more general role in translational fidelity. In 
 this work\, they demonstrate that the features of nascent polypeptides alo
 ne are capable of triggering efficient -1PRF\, which typically results in 
 the premature termination of translation. They provide evidence that cotra
 nslational feedback between nascent chains\, translocons\, and ribosomes a
 llows the translational machinery to terminate protein synthesis in respon
 se to misfolding of the nascent chain or the incorrect splicing of a trans
 cript. Their findings suggest feedback between the nascent chain and ribos
 ome may play a more general role in the negative regulation of translation
 .\n\nHosted by Willow Coyote-Maestas
GEO:37.767173;-122.392156
LOCATION:Genentech Hall\, N114
SUMMARY:Cotranslational Assembly Defects Trigger a Proteostatic Killswitch 
 in the Ribosome
URL;VALUE=URI:https://calendar.ucsf.edu/event/cotranslational-assembly-defe
 cts-trigger-a-proteostatic-killswitch-in-the-ribosome
END:VEVENT
END:VCALENDAR