The 2017 Cell Mapping Symposium will address research and technology advances in cell mapping as it relates to cancer, psychiatric disorders, and infectious disease.
The ability of a cell to respond to its environment depends on the actions of the proteins encoded by the DNA in the genome. However, most proteins don’t work alone. They work with other proteins in teams called complexes. The principles of “cell mapping” are to figure out which proteins work together in complexes. Mapping can be done in different disease states or in the presence of different chemical drugs. To accomplish these goals, researchers augment these cell maps with genetic maps to derive quantitative insights into how biological functions of cells can be restored.
One of the main objectives of this symposium is to discuss technological advances in extracting mechanistic insight from these large genome sequencing projects. These efforts include using proteomic, biochemical, genetic, and structural biology approaches to generate cellular maps that can be used to interpret this genomic data from a variety of different disease areas.
The 2017 Cell Mapping Symposium, will be held over 2 days, Sept. 13-14, at Gladstone Institutes in San Francisco’s Mission Bay neighborhood. The symposium will start at 1:00 pm on Sept. 13th, at the Mahley Auditorium and end at 5:00 pm on Sept. 14th. Confirmed speakers for the symposium are listed below.
Dave Agard, UC San Francisco - "Using CryoEm to understand dynamic protein complexes"
Cori Bargmann, Chan-Zuckerberg Science & The Rockefeller University - “Diversity of cellular function in the nervous system”
Michael Boutros, DKFZ - "Mapping genetic interaction networks (in cancer cells)"
Jasmin Fisher, University of Cambridge & Microsoft Research - "Deconstructing Cancer Networks Using Executable Biology"
Jennifer Grandis, UC San Francisco
Rick Horwitz, Allen Institute - "Integrated spatial-temporal stem cell biology - a next step in the post genomic era"
Trey Ideker, UC San Diego
Martin Kampmann, UC San Francisco - "Mapping neuronal cell biology in health and disease with CRISPRi and CRISPRa"
Nevan Krogan, Gladstone Institutes & UC San Francisco
Kasper Lage, Massachusetts General Hospital, Stanley Center at the Broad Institute & Harvard Medical School - “Large-scale protein-protein interaction experiments of schizophrenia risk genes in human neurons coalesce GWAS loci into unexpected pathways"
Joana Loizou, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences -"Rebalancing DNA repair pathways in disease"
Kathryn Miller-Jensen, Yale University
Clodagh O' Shea, Salk Institute
Teresa Przytycka, NCBI, NIH - "New methods to uncover properties of mutational landscape in cancer"
Ben Raphael, Princeton University
Andrej Sali, UC San Francisco - Integrative structural biology
Laura Van’t Veer, UC San Francisco
Mark Von Zastrow, UC San Francisco - "Spatiotemporal dynamics of protein interaction networks in living cells"
Thursday, September 14, 2017 at 9:00am to 5:00pm
Gladstone Institutes, Mahley Auditorium 1650 Owens St, San Francisco, CA 94158