Hosted by the UCSF Helen Diller Family Comprehensive Cancer Center, this symposium will bring together leaders in functional genomics and cancer therapeutics, focusing on bridging the gap between genomics and the development of effective treatments. Researchers within the National Cancer Institute's Cancer Target Discovery and Development (CTD²) Network will highlight advancements in understanding tumor development, heterogeneity, drug resistance, and metastasis.

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AGENDA

10 - 10:15 am | Welcome and Opening Remarks
Trever Bivona, MD, PhD and Mike McManus, PhD

10:15 - 10:35 am | Modeling Chromosomal Instability in Cancer
Ronald DePinho, MD, Professor of Cancer Biology - Division of Discovery Science, MD Anderson Cancer Center

10:35 - 10:55 am | Elucidating proteins-wide drug mechanism of action
Andrea Califano, Dr, Professor of Chemical and Systems Biology, Columbia University Irving Medical Center

10:55 - 11:15 am | Modeling and drugging N-myc driven cancers
William (Bill) Weiss, MD, PhD, Professor of Neurology, UCSF

11:15 - 11:45 am | Break

11:45 am - 12:05 pm| Deciphering mechanisms of immunotherapy response and resistance in hepatobiliary cancers
Bridget Keenan, MD, PhD, Assistant Professor of Medicine - Division of Hematology/Oncology, UCSF

12:05 - 12:45pm | Targeting treatment resistance from functional genomics to therapeutic development in ovarian cancer
Katherine Fuh, MD, PhD, Associate Professor of Ob/Gyn & Reproductive Sciences, UCSF

12:25 - 12:45 pm | A patient-centric approach to advance functional precision oncology
Christopher Kemp, PhD, Professor, Division of Human Biology, Fred Hutchinson Cancer Research Center 

12:45  -1:45pm  | Lunch

1:45 - 2:05 pm | Title TBD
Trever Bivona, MD, PhD, Professor of Medicine - Division of Hematology/Oncology, UCSF

2:05 - 2:25 pm |Synthetic lethality in cancer cells: paralogs and beyond
Traver Hart, PhD, Associate Professor of Bioinformatics and Computational Biology, MD Anderson Cancer Center

2:25 - 2:45pm | Uncovering metabolic dependencies in primary versus metastatic pancreatic cancer
Rushika Perera, PhD, Associate Professor of Anatomy, UCSF

2:45 - 3:15 pm | Break

3:15 - 3:35 pm | Tracking cell-cell interactions using intercellular barcode transfer
Neil Tay, PhD, Postdoctoral Scholar (McManus Lab), UCSF 

3:35 - 3:55 pm | The genome in precision medicine: Understanding the role of an insertion/deletion variant in breast cancer progression
Paola Betancur, PhD, Assistant Professor of Radiation Oncology, UCSF

3:55 - 4:15pm | Closing Remarks
Trever Bivona, MD, PhD and Mike McManus, PhD

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> REGISTER TO ATTEND

This event is in person only. Lunch will be provided. Open to the internal UCSF community.