DPBS Trainee Research Award Presentations (Part II)

Control of Fear States and Underlying Neural Dynamics by Respiratory Rhythms

Alexandra Klein, PhD • Postdoctoral Scholar • Department of Psychiatry and Behavioral Sciences • UCSF Weill Institute for Neurosciences

From Receptors to Behavior: Rethinking Drug Discovery in Psychiatry

Chimno Nnadi, MD, PhD • Resident Physician • Adult Psychiatry Residency Training Program • Department of Psychiatry and Behavioral Sciences • UCSF Weill Institute for Neurosciences

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Learning objectives for Dr. Klein's presentation:
Upon completion of this activity, participants will be able to:

• Explain what interoception is
• Name the brain region that controls breathing and the subset of neurons that are hypothesized to transmit respiratory interoceptive signals to higher-order brain regions
• List at least two brain regions that synchronize with the breathing rhythm

Learning objectives for Dr. Nnadi's presentation:
Upon completion of this activity, participants will be able to:

• Identify at least one key limitation of target-based approaches that contributes to high failure rates in psychiatric drug discovery
• Describe how behavior can be used as a primary, quantitative endpoint in drug screening, rather than a downstream readout
• Explain how machine learning applied to behavioral data can reveal pharmacologically meaningful patterns, including classification of compound activity and generation of new therapeutic hypotheses

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In addition to the Pritzker Building, DPBS members can also watch this event live at Mount Zion (Room B730) and ZSFG (Bldg. 5, Room 7E12), as well as on Zoom (psychiatry.ucsf.edu/watchgrandrounds).

Psychiatry and Behavioral Sciences Grand Rounds presentations are for educational purposes and intended only for behavioral/mental health professionals and clinical providers.

Continuing education (CE) credit is available for physicians, psychologists, nurses, and therapists who participate in this activity.