Translational Strategies for Understanding Neural Circuitry Dysfunction in Schizophrenia

David A. Lewis, MD
Chair, Dept. of Psychiatry
Distinguished Professor of Psychiatry and Neuroscience
Thomas Detre Professor of Academic Psychiatry
Director, Translational Neuroscience Program
Medical Director, UPMC Western Psychiatric Hospital
Director of Research, UPMC Western Psychiatric Hospital
Univ. of Pittsburgh

Learning objectives:
Upon completion of this activity, participants will be able to:

• Understand the importance of cognitive dysfunction to functional outcomes in schizophrenia
• Understand the neural circuitry basis for cognitive dysfunction in schizophrenia
• Understand the potential for targeting altered neural circuits to enhance cognitive function in schizophrenia
   

About the speaker:
Dr. Lewis is Distinguished Professor of Psychiatry and Neuroscience, Thomas Detre Professor of Academic Psychiatry, Chair of the Department of Psychiatry, and Director of the Translational Neuroscience Program at the University of Pittsburgh, as well as Medical Director and Director of Research at UPMC Western Psychiatric Hospital. His clinical interests and research activities focus on schizophrenia, with emphasis on the core clinical features (cognitive impairments) of the illness that reflect dysfunction of neural circuits in the prefrontal cortex and related brain regions.

Dr. Lewis received his medical degree from the Ohio State University, completed residencies in both internal medicine and psychiatry at the University of Iowa, and received his research training at the Research Institute of the Scripps Clinic. His research findings have been published in more than 600 scientific articles. Recognition of Dr. Lewis’ research accomplishments has included the Lieber Prize for Schizophrenia Research from NARSAD, the William K. Warren Award from the International Congress of Schizophrenia Research, the Stanley Dean Research Award from the American College of Psychiatrists, the American Psychiatric Association’s Research Award, the Gold Medal Award from the Society of Biological Psychiatry, and NIMH Senior Scientist and MERIT Awards. He is an elected member of the National Academy of Medicine and of the Association of American Physicians.

Dr. Lewis currently serves as Deputy Editor of the American Journal of Psychiatry, on the scientific councils for the Brain and Behavior Research Foundation and the Simons Foundation Autism Research Initiative, and on the Board of Directors of the Pittsburgh Foundation, the Charles Kaufman Foundation and Community Care Behavioral Health. He previously served as a member of the National Advisory Mental Health Council, as President of the American College of Neuropsychopharmacology and of the Society of Biological Psychiatry and, for 25 years as Director of a NIMH Conte Center for Translational Mental Health Research. 

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In addition to the Pritzker Building, DPBS members can also watch this event live at Mount Zion (Room B730) and ZSFG (Bldg. 5, Room 7M30), as well as on Zoom (psychiatry.ucsf.edu/watchgrandrounds).

Psychiatry and Behavioral Sciences Grand Rounds presentations are for educational purposes and intended only for behavioral/mental health professionals and clinical providers.

Continuing education (CE) credit is available for physicians, psychologists, nurses, and therapists who participate in this activity.