Trainee Research Award Presentations, Part I

Defining the Physiological Role of a Type I Interferon-Responsive Microgial Subset in Cortical Development

Caroline Escoubas, MD, PhD
Postdoctoral Scholar
Department of Psychiatry and Behavioral Sciences
UCSF Weill Institute for Neurosciences

Mismatch Negativity and Theta Oscillations Evoked by Auditory Deviance in Early Schizophrenia

Jessica Hua, PhD
Assistant Adjunct Professor
Department of Psychiatry and Behavioral Sciences
UCSF Weill Institute for Neurosciences

Learning objectives for Dr. Escoubas' presentation:

• Discuss one way that microglia can remodel brain circuits during early development 
• Discuss the role for Type I interferon responses in the central nervous system outside of viral infection
• Discuss how alteration in microglial function can lead to sensory processing phenotypes

Learning objectives for Dr. Hua's presentation:

• Define mismatch negativity event related potential response to auditory deviants and its reduction in schizophrenia, including during the early stages of the disorder
• Discuss the evidence that stimulus-evoked theta oscillations underlie the mismatch negativity to auditory deviance, including the correlation between them.
• Discuss whether auditory-deviance evoked theta oscillations and mismatch negativity are sensitive to distinct or overlapping pathophysiological processes in schizophrenia

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UCSF Department of Psychiatry and Behavioral Sciences Grand Rounds presentations are for educational purposes and intended only for behavioral/mental health professionals and clinical providers.

Continuing education (CE) credit is available for physicians, psychologists, nurses, and therapists who participate in this activity.